Definitely personal preference.
In our case, we used the same size pulls on all drawers (4"). We used one pull on drawers = 30". We have 18", 24", 27", 30", 31", 31.5", 33", and 36" drawers and, like you, the vast majority of our bases are drawer bases. The only exceptions are the sink bases and the 6" pullouts flanking the cooktop.
Cup pulls vs "regular" pulls...originally I wanted cup pulls, but then when we realized that to open the bottom drawers you have to reach under to get your hand in the pull that it would be more difficult than just reaching down from the top, we went w/the "regular". In the end, I'm glad we did as I like our pulls better than the cup pulls for our cabinets & kitchen style.
The issue of being able to fit my DH's bigger hands was a concern for us as well when we were considering the cup pulls; since you're also concerned, I'd buy a couple of the larger pulls and try them out. We bought several different pulls & knobs and tried them on our old cabinets to get a feel for what they would be like using them as well as to get a general idea of what they would look like.
24" Drawer, 1 pull/drawer:
27" Drawer, 1 pull/drawer:
33" Drawer, 2 pulls/drawer and 18" Drawer, 1 pull/drawer & trash pullout:
36" Drawer, 2 pulls/drawer:
Q
